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This account describes the chemistry of the bioactive compounds isolated from the sea hares belonging to two genera: Aplysia and Dolabella. The bioactive compounds are classified as i) polyketides, ii) terpenes, iii) peptides and depsipeptides, and iv) others. Special emphasis is placed on the chemistry of cytotoxic compounds such as aplyronines and dolastatins that were obtained in our laboratory: Their isolation, structural elucidation, synthesis, and selected bioactivities data are summarized.
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Yamada et al. (1997) studied this question.
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