Nephron Sparing Partial Nephrectomy for Renal Cell Carcinoma in Transplanted Kidney After Simultaneous Pancreas-Kidney Transplantation - First Report of Two Cases

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Simultaneous pancreas-kidney transplantation (SPK) is one of the treatment options for type 1 diabetes mellitus with end-stage renal failure. Solid organ transplant recipients are more susceptible to developing post-transplant cancers, including renal cell carcinoma compared to the general population. While the incidence of renal cell carcinoma is up to 10 times higher in kidney-only transplant recipients, reports of renal cell cancers in renal grafts after SPK transplantation are rare and successful nephron sparing partial nephrectomy has not yet been reported in literature. We present herein the case report of two patients, aged 47 and 54 years old, who underwent a successful partial nephron-sparing graft nephrectomy for clear cell and papillary renal cell carcinoma ten and fourteen years after his SPK transplant respectively. Both patients made a full recovery after surgery and maintained good renal function in the respective 12-month and 9-month postoperative period.