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November 11, 2016Frontiers in ImmunologyOpen Access

Viral Evasion Strategies in Type I IFN Signaling – A Summary of Recent Developments

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Key result

Viruses have evolved diverse strategies to evade the innate immune response by interfering with various steps of the Type I interferon signaling cascade.

Design

Review

Authors

KSKatharina S. SchulzKMKaren MossmanMcMaster University

Discussion

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Overview

May support antiviral strategies restoring type I interferon; leaves open clinical efficacy trials.

PICO

P
Population
Viral infections

This review highlights the diverse molecular strategies employed by viruses to evade the host type I interferon response, providing insights for potential antiviral therapies.

Limitations

  • Use of clinical isolates versus laboratory-passaged strains could yield different results
  • Choice of cell line can greatly influence experimental outcomes
  • Use of genetic knockout versus knockdown cell lines or organisms can influence experimental outcomes
  • Overexpression approaches can disrupt endogenous interactions
  • Endogenous interactions are disrupted with the use of overexpression approaches

Cite This Study

Schulz et al. (2016) conducted a review in Viral infections. Viruses have evolved diverse strategies to evade the innate immune response by interfering with various steps of the Type I interferon signaling cascade.

synapsesocial.com/papers/6a97156b2d8f86faeeb3059dhttps://doi.org/10.3389/fimmu.2016.00498
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