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February 16, 1999Proceedings of the National Academy of SciencesOpen Access

On the mechanism by which vascular endothelial cells regulate their oxygen consumption

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Key result

Endogenous nitric oxide generated by vascular endothelial cells modulates their respiration in response to acute changes in oxygen concentration by acting on cytochrome c oxidase.

Population

Endothelial cells prepared from fresh porcine thoracic aortae

Comparison

Modulation of endogenous nitric oxide production… vs Control cells without NOS inhibitors or…

Design

Preclinical

Authors

ECEmilio ClementiUniversity of MilanGBGuy C. BrownUniversity of CambridgeNFNeale FoxwellWolfson Foundation

Discussion

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Implication

Animal data suggest endothelial NO aids acute oxygen sensing; leaves open translation to human vascular disease or therapy.

Structured PICO

P
Population
Endothelial cells prepared from fresh porcine thoracic aortae
E
Exposure
Modulation of endogenous nitric oxide (NO) production using bradykinin, ATP, and NOS inhibitors (L-NAME) under varying oxygen concentrations
C
Comparator
Control cells without NOS inhibitors or stimulation
O
Outcome
Rate of cellular oxygen consumption and NO generationsurrogate

Endogenous nitric oxide plays a physiological role in adjusting the capacity of cytochrome c oxidase to use oxygen, allowing endothelial cells to adapt to acute changes in oxygen concentration.

Cite This Study

Clementi et al. (1999) studied this question. Endogenous nitric oxide (NO) vs. NOS inhibition (L-NAME) or control cells was evaluated on Oxygen consumption rate. Endogenous nitric oxide generated by vascular endothelial cells modulates their respiration in response to acute changes in oxygen concentration by acting on cytochrome c oxidase.

synapsesocial.com/papers/6a9716b4a43071aed1f6ca81https://doi.org/10.1073/pnas.96.4.1559
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Also Consider

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  5. 5Oxygen dependence of mitochondrial function in isolated rat cardiac myocytes1986 · 98 citations