What question did this study set out to answer?

To evaluate coronary collateral structure and function in pigs and examine blood flow distribution across lateral and transmural ischemic border zones following acute arterial occlusion.

January 1, 1983AJP Heart and Circulatory Physiology

Analysis of coronary collateral structure, function, and ischemic border zones in pigs

View Full Paper

Ask AI

Bookmark

Authors

RPRandolph E. PattersonUniversity of North Carolina at Chapel Hill EKEdward S. KirkUniversity of Illinois Urbana-Champaign

Discussion

Member takes

Implication

Experimental study demonstrates minimal coronary collateral blood flow following acute arterial occlusion in pigs, indicating limited suitability as an ischemic heart disease model.

Key Points

To evaluate coronary collateral structure and function in pigs and examine blood flow distribution across lateral and transmural ischemic border zones following acute arterial occlusion.
Induced acute occlusion of the left anterior descending coronary artery (LAD) in N=26 anesthetized open-chest pigs.
Quantified collateral perfusion via retrograde flow, microsphere-derived myocardial blood flow, and postmortem distal LAD injection with tissue clearing.
Collateral perfusion after occlusion was minimal, with retrograde flow measuring 0.2 ± 0.1 ml/min and microsphere blood flow measuring 0.005 ± 0.001 ml·min⁻¹·g⁻¹.
No measurable collateral blood flow gradient occurred across the transmural border zone, and flow remained unaltered by retrograde drainage or elevated left ventricular filling pressure.
Elevated blood flow in the lateral border zone was driven by anatomical overlap of unoccluded and occluded arterial branches rather than preferential collateral perfusion.

Cite This Study

Patterson et al. (1983) studied this question.

synapsesocial.com/papers/6a9718aaff8a6b2115f6de94 https://doi.org/10.1152/ajpheart.1983.244.1.h23

View Full Paper

Ask AI

Bookmark

Implication

Experimental study demonstrates minimal coronary collateral blood flow following acute arterial occlusion in pigs, indicating limited suitability as an ischemic heart disease model.

Analysis of coronary collateral structure, function, and ischemic border zones in pigs

Discussion

Member takes

Implication

Key Points

Cite This Study

Analysis of coronary collateral structure, function, and ischemic border zones in pigs

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider