Answers are grounded in this paper and cite their sources.
The identification of proteins and the co-/post-translational modifications that characterize their mature (active) forms is central to proteomic experimentation. This has been accomplished historically using a variety of methods, but mass spectrometry, and in particular tandem applications (MS/MS), has become the core technology because of its efficiency, accuracy, and sensitivity. When coupled to various separation methodologies, it can produce hundreds of identifications from a single complex sample.
No takes yet. Share an insight, caveat, or question.
Bradshaw et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: