Key result
Short-term fenofibrate therapy significantly decreased estimated glomerular filtration rate by 18.6% compared to a 0.9% increase in the control group among patients with hypertriglyceridemia.
Why the study?
Does short-term fenofibrate therapy increase blood creatinine levels and impair renal function in patients with hypertriglyceridemia?
Population
86 hypertriglyceridemic patients with normal baseline renal function, mean age ~55 years, predominantly…
Comparison
Micronized fenofibrate 160 mg once daily… vs Diet therapy education only for 2 months.
Design
Cohort
Follow-up
2 months
Authors
Loading...
May warrant renal monitoring with short-term fenofibrate; leaves open causality and long-term relevance in hypertriglyceridemia.
Cohort (n=86)
No
Does short-term fenofibrate therapy increase blood creatinine levels and impair renal function in patients with hypertriglyceridemia?
Absolute Event Rate: -18.6% vs 0.9%
p-value: p=<0.001
Short-term fenofibrate therapy significantly impairs renal function by increasing serum creatinine and decreasing eGFR in hypertriglyceridemic patients, an effect that is more pronounced in the elderly.
Hyeon et al. (2014) conducted a cohort in Hypertriglyceridemia (n=86). Fenofibrate vs. Dietary therapy only (Control) was evaluated on Percent change in estimated glomerular filtration rate (eGFR) (p=<0.001). Short-term fenofibrate therapy significantly decreased estimated glomerular filtration rate by 18.6% compared to a 0.9% increase in the control group among patients with hypertriglyceridemia.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: