What question did this study set out to answer?

To assess the correlation of dual-energy X-ray absorptiometry (DEXA) with dual-photon absorptiometry (DPA), its capacity to discriminate spinal osteoporosis, and its long-term measurement reproducibility.

September 1, 1991Journal of Bone and Mineral Research

Precision and sensitivity of dual-energy X-ray absorptiometry in spinal osteoporosis

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To assess the correlation of dual-energy X-ray absorptiometry (DEXA) with dual-photon absorptiometry (DPA), its capacity to discriminate spinal osteoporosis, and its long-term measurement reproducibility.
Measured spine bone mineral density (BMD) in 112 subjects and femur BMD in 22 subjects using both DEXA and DPA to assess cross-technology correlation.
Evaluated DEXA spine and femur BMD in 80 women with spinal osteoporosis (mean age 61 years) compared to 110 age-matched normal controls using receiver operating characteristic (ROC) curves.
Quantified long-term precision error over a 1-year period in a phantom model in vitro, as well as in vivo among young adults and osteoporotic subjects.
DEXA and DPA measurements were highly correlated across spinal and femoral regions (r > 0.9, SEM = 0.02 to 0.04 g/cm²).
Osteoporotic women showed significant reductions in L2–4 spine BMD (-23%, Z-score = 2.6) and femur BMD (-13% to -20%, Z-score = 1.1–1.3), with L2–4 BMD providing an ROC area under the curve of 94% versus 84% for Ward's triangle.
One-year precision error was 0.7% in vitro, approximately 1% (SD = 0.012 g/cm²) at L2–4 in young adults, and SD = 0.017 g/cm² in osteoporotic patients.

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Implication

Comparative study demonstrates high diagnostic accuracy and precision of dual-energy X-ray absorptiometry in spinal osteoporosis, indicating its utility for assessing bone loss.

Cite This Study

Pouillès et al. (1991) studied this question.

synapsesocial.com/papers/6a971ca3c00de92d9bfbe522 https://doi.org/10.1002/jbmr.5650060914

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Implication

Comparative study demonstrates high diagnostic accuracy and precision of dual-energy X-ray absorptiometry in spinal osteoporosis, indicating its utility for assessing bone loss.

Precision and sensitivity of dual-energy X-ray absorptiometry in spinal osteoporosis

Key Points

Discussion

Implication

Cite This Study

Precision and sensitivity of dual-energy X-ray absorptiometry in spinal osteoporosis

Key Points

Discussion

Implication

Cite This Study

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