Key result
Live oral rotavirus vaccines elicited significant serum IgA and IgG antibody responses to homotypic and heterotypic NSP4s, whereas IgA responses to VP4 were predominantly homotypic.
Why the study?
What are the homotypic and heterotypic serum isotype-specific antibody responses to rotavirus proteins in infants receiving live oral rotavirus vaccines?
Observational
What are the homotypic and heterotypic serum isotype-specific antibody responses to rotavirus proteins in infants receiving live oral rotavirus vaccines?
Live oral rotavirus vaccines induce significant homotypic and heterotypic antibody responses to NSP4 and VP7, while responses to VP4 are predominantly homotypic.
Supports NSP4 as a potential broad-spectrum antigen; leaves open whether responses predict clinical protection.
Homotypic and heterotypic serum isotype-specific antibody responses to rotavirus enterotoxin nonstructural protein (NSP)-4, independent neutralization antigens viral protein (VP)-4 and VP7, and group A rotavirus common antigen VP6 were analyzed by an immunocytochemistry assay in infants who received 1 of several live oral rotavirus vaccines. Significant serum immunoglobulin (Ig) A and IgG antibody responses to homotypic and/or heterotypic NSP4s of genotype [A], [B], or [C] were detected after vaccination. The magnitude of antibody responses to homotypic and heterotypic NSP4s was not significantly different, irrespective of the NSP4 genotype of the administered vaccine strain. In addition, there were no significant differences between IgA antibody responses to homotypic and heterotypic VP7s. In contrast, IgA antibody responses to VP4 were predominantly homotypic. IgA antibody responses to VP7 were lower in magnitude than those to VP4 but were comparable to those to NSP4. Antibody titers to homotypic and/or heterotypic NSP4s were positively correlated with those to VP6 before and after vaccination.
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Yuan et al. (2004) conducted an observational in Rotavirus vaccination. Live oral rotavirus vaccines was evaluated on Serum isotype-specific antibody responses to rotavirus NSP4, VP4, VP6, and VP7. Live oral rotavirus vaccines elicited significant serum IgA and IgG antibody responses to homotypic and heterotypic NSP4s, whereas IgA responses to VP4 were predominantly homotypic.
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