Key result
Vaccination against foot-and-mouth disease resulted in protective antibodies to the type A virus in only 66% of cattle, indicating low field efficacy and a mismatch with the epizootic strain.
Observational (n=1,015)
Field efficiency of foot-and-mouth disease vaccines in cattle can vary and requires continuous monitoring of post-vaccinal antibodies to ensure herd immunity.
Suboptimal FMD seroprotection in cattle cautions against assuming reliable herd immunity; leaves open need for strain-matched vaccines and prospective monitoring studies.
A retrospective analysis of the epizootic situation with foot-and-mouth disease in Krasnodar region has been provided in 2013. Results of study indentified, type A, Asia topotype, Iran 05 genetic lines, SIS-10 sub-linage has been identified for foot-and-mouth disease. Laboratory tests proved that over 75% of animals were immune in the blood collected after 60-80 days vaccination. Field efficiency of foot-andmouth disease vaccines does not always correspond to the characteristics obtained during the quality control of the vaccine manufacturer. If master seed strain matches epizootic isolates, mass vaccination creates herd immunity, prevents an outbreak, and stabilizes the epizootic process that has begun. Taking into consideration the threat of penetration of the virus into the territory of Russia, regular vaccination of ruminant animals and control of the level of vaccine-induced antibodies are required in the buffer zone.
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Chernykh et al. (2017) conducted an observational in Foot-and-mouth disease (n=1,015). Foot-and-mouth disease vaccination was evaluated on Presence of postvaccinal foot-and-mouth antibodies to type A virus. Vaccination against foot-and-mouth disease resulted in protective antibodies to the type A virus in only 66% of cattle, indicating low field efficacy and a mismatch with the epizootic strain.
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