Key result
The eNOS 894G>T TT genotype was significantly associated with an increased risk of diabetic nephropathy progression to an eGFR < 30 ml/min/1.73 m2 (aOR 4.180).
Why the study?
The eNOS gene is considered a possible susceptibility gene for diabetic nephropathy, but how the eNOS Glu298Asp gene polymorphism contributes to disease progression was unclear.
Does the eNOS Glu298Asp gene polymorphism (894G > T) predict the progression of kidney disease in patients with diabetic nephropathy?
Cross-Sectional (n=100)
No
Does the eNOS Glu298Asp gene polymorphism (894G > T) predict the progression of kidney disease in patients with diabetic nephropathy?
Odds Ratio: 4.18 (95% CI 1.271–13.749)
p-value: p=0.019
The eNOS 894G>T polymorphism, specifically the TT genotype, is associated with a significantly increased risk of severe eGFR reduction in Egyptian patients with type 2 diabetic nephropathy.
eNOS 894 TT genotype was associated with diabetic nephropathy progression; hypothesis-generating, requires prospective validation before clinical consideration.
Background: Interactions between hereditary and environmental variables cause diabetic nephropathy (DN) which is a complex illness. Consideration has been given to the eNOS gene as a possible susceptibility gene for DN. Objective: We aimed to determine how the eNOS Glu298Asp gene polymorphism (894G > T) contributes to DN progression. Methods: This cross-sectional study involved 100 patients with type 2 diabetes (T2DM) and having DN diagnosed with albuminuria (urinary albumin/creatinine ratio (ACR) > 30 mg/g), recruited from Tanta University hospitals inward and outpatient clinics. Both groups were divided based on the participants' estimated glomerular filtration rates (eGFR): 50 type 2 DN patients with an eGFR greater than 30 ml/min/1.73 m2 were included in group I, while 50 type 2 DN patients with an eGFR less than 30 ml/min/1.73 m2 were included in group II. A comprehensive history and physical examination were conducted on each patient. Their body mass index was measured, their lipid profiles were reviewed, their blood urea and serum creatinine levels were measured, and the patients' eGFR was calculated using the CKD-EPI equation. The patients were also genotyped for the eNOS 894G > T gene polymorphism using the PCR-RFLP technique. Results: TT genotype and T allele were found to be higher in DN group with eGFR 30 ml/min/1.73 m2 (p = 0.128, 0.120 respectively), and it could predict the risk for DN progression particularly in recessive model (aOR: 0.019, 95% C.I: 1.271-13.749). Conclusion: Because of its predictive power for DN advancement, eNOS 894G>T deserves further research as a major genetic marker for eGFR reduction and DN progression in type 2 Egyptian diabetic patients.
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Radwan et al. (2025) conducted a cross-sectional in Diabetic nephropathy in type 2 diabetes (n=100). eNOS 894G>T TT genotype vs. eNOS 894G>T GG and GT genotypes was evaluated on Progression of diabetic nephropathy (eGFR < 30 ml/min/1.73 m2) (aOR 4.180, 95% CI 1.271-13.749, p=0.019). The eNOS 894G>T TT genotype was significantly associated with an increased risk of diabetic nephropathy progression to an eGFR < 30 ml/min/1.73 m2 (aOR 4.180).
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