What question did this study set out to answer?

Evaluate the clinical utility of advanced proteomic technologies and urine sampling for discovering novel diagnostic and prognostic biomarkers in prostate cancer.

January 1, 2006Biomarkers

Application of proteomic strategies to the identification of urinary biomarkers for prostate cancer: A review

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Authors

MDMichelle DownesUniversity College Dublin JBJennifer C. ByrneUniversity College Dublin MDMichael J. DünnBrigham Young University

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Implication

Review highlights the utility of urinary proteomics in prostate cancer, suggesting noninvasive biofluid analysis improves diagnostic and prognostic specificity.

Key Points

Evaluate the clinical utility of advanced proteomic technologies and urine sampling for discovering novel diagnostic and prognostic biomarkers in prostate cancer.
Reviewed high-throughput proteomic platforms, including mass spectrometry and modern quantitative proteomic workflows.
Synthesized current literature regarding urinary proteome characterization and its translational potential in prostate malignancy.
Identified urine as an advantageous, noninvasive biofluid that reflects local biochemical alterations caused by prostate malignancy.
Determined that quantitative mass spectrometry platforms provide the throughput and sensitivity needed to distinguish disease-specific protein alterations from general biological variation.

Cite This Study

Downes et al. (2006) studied this question.

synapsesocial.com/papers/6a971ec50f79e4f014b3242f https://doi.org/10.1080/13547500600799821

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Implication

Review highlights the utility of urinary proteomics in prostate cancer, suggesting noninvasive biofluid analysis improves diagnostic and prognostic specificity.

Application of proteomic strategies to the identification of urinary biomarkers for prostate cancer: A review

Discussion

Member takes

Implication

Key Points

Cite This Study

Application of proteomic strategies to the identification of urinary biomarkers for prostate cancer: A review

Discussion

Member takes

Implication

Key Points

Cite This Study

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