Key result
Right lower ganglionated plexi ablation significantly reduced the proportion of sites producing AV block during high frequency stimulation compared to other GP ablation (13.3% vs 100%; P<0.005).
Why the study?
Does targeted ablation of specific ganglionated plexi or pulmonary vein isolation disrupt the neural pathways connecting the left atrium to the AV node, SA node, and pulmonary veins in patients with atrial fibrillation?
Population
30 patients undergoing left atrial ablation with autonomic modification, including patients with persistent…
Comparison
Ablation of specific ganglionated plexi or… vs Ablation of other GPs or pre-ablation baseline…
Design
Cohort
Authors
Loading...
May guide selective right lower GP ablation to spare AV conduction in AF; hypothesis-generating for neural mapping strategies pending RCTs.
Does targeted ablation of specific ganglionated plexi or pulmonary vein isolation disrupt the neural pathways connecting the left atrium to the AV node, SA node, and pulmonary veins in patients with atrial fibrillation?
Absolute Event Rate: 13.3% vs 100%
p-value: p=<0.005
The study maps the neural pathways of the left atrial ganglionated plexi, demonstrating that connections to the AV node travel via the right lower GP and to the SA node via the right upper GP, providing mechanistic insights into how PV isolation prevents atrial fibrillation.
Malcolme‐Lawes et al. (2013) studied Atrial fibrillation (n=30). Right lower ganglionated plexi (GP) ablation vs. Ablation of other GPs (leaving right lower GP intact) was evaluated on Positive sites producing AV block during high frequency stimulation (p=<0.005). Right lower ganglionated plexi ablation significantly reduced the proportion of sites producing AV block during high frequency stimulation compared to other GP ablation (13.3% vs 100%; P<0.005).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: