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COELIAC DISEASE D JU 823then further degraded to amino-acids by peptidases present in the cells of the mucosa.In adult coeliac disease it is suggested that the activity of these cellular enzymes is reduced, and this, in addition to a reduction in absorptive area, produces a slowing down in the later stages of proteolysis.The possibility that the changes of absorption observed in the hydrolysis are associated with the rate of absorption of water has been excluded by appropriate control experiments.It was of interest that treatment for several weeks with a glutenfree diet in one of our cases produced a normal type of absorption, as shown by the results of isotope experiments.
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E Ask-Upmark (1960) studied this question.
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