DVa Category Phenotype and Genotype in Japanese Families

Background and Objectives: The genetic background of the DVa category phenotype has been described in two Caucasian individuals. We were interested in the RHD sequence of 7 Japanese DVa individuals and their families. Materials and Methods: With SSP‐PCR we tested exons 4, 5 and 7 of the RHD gene and used restriction enzymes for testing nucelotide associated with the DVa phenotype. Results: A single RHD G667 C697 allele was present in 5 individuals with DVa category phenotype, and in 2 individuals we found a D‐CE‐D hybrid gene (exon 5 had been replaced). The DVaCe gene complex was found in all families. Conclusion: The changes of the RHD gene described in European DVa individuals were also observed in Japanese families.