Key result
The NO donor SIN-1 decreased oxygen consumption in contracting (-21%) and quiescent (-24%) isolated rat cardiomyocytes, likely via direct inhibition of the respiratory chain.
Population
Isolated cardiomyocytes of Wistar rats
Comparison
Nitric oxide donors vs Baseline and SIN-1C
Design
Preclinical
Authors
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Effects confined to isolated rat cells; leaves open in vivo relevance to human cardiac energetics.
Nitric oxide directly inhibits the respiratory chain in isolated cardiomyocytes, decreasing cardiac respiration and reducing energy status in quiescent cells.
Stumpe et al. (2001) studied this question. Nitric oxide (NO) donor morpholinosydnonimine (SIN-1) was evaluated on Oxygen consumption (VO2). The NO donor SIN-1 decreased oxygen consumption in contracting (-21%) and quiescent (-24%) isolated rat cardiomyocytes, likely via direct inhibition of the respiratory chain.
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