What question did this study set out to answer?

To evaluate how asthma exacerbations influence longitudinal changes in patient-reported outcome measures (PROMs) and whether asthma-specific PROMs can predict exacerbations in adults with severe asthma receiving usual care.

December 20, 2024Health and Quality of Life OutcomesOpen Access

Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED

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Authors

RMRoy MeysMaastricht University Medical Centre FFFrits M.E. FranssenJanssen (Belgium)AHAlex J. van ‘t HulRadboud University Nijmegen

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Implication

Cohort study reveals patient-reported outcome measures change with exacerbations in severe asthma, indicating routine PROM monitoring aids personalized care.

Key Points

To evaluate how asthma exacerbations influence longitudinal changes in patient-reported outcome measures (PROMs) and whether asthma-specific PROMs can predict exacerbations in adults with severe asthma receiving usual care.
Analyzed adult participants with severe asthma from the prospective U-BIOPRED cohort who received usual care.
Evaluated PROMs at baseline and after 12 to 18 months, including the ACQ5, AQLQ, HADS, ESS, MARS, and SNOT20 surveys alongside clinical biomarkers like FeNO and eosinophils.
PROMs showed poor association with baseline clinical markers including FeNO and eosinophilic cell counts.
Patients experiencing no exacerbations during follow-up achieved statistically significant improvements across all PROMs except MARS, whereas those with more than two exacerbations experienced deterioration.
Baseline ACQ5 weakly predicted exacerbations, yielding an area under the receiver operating characteristic curve of 0.590 (95% CI 0.514–0.666).

Cite This Study

Meys et al. (2024) studied this question.

synapsesocial.com/papers/6a97282bd005bc9a5c3db0d1 https://doi.org/10.1186/s12955-024-02321-3

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Implication

Cohort study reveals patient-reported outcome measures change with exacerbations in severe asthma, indicating routine PROM monitoring aids personalized care.

Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED

Discussion

Member takes

Implication

Key Points

Cite This Study

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