Ailure to Demonstrate Increased Hypersensitivity to Egg Protein after Immunization with an Influenza Vaccine of the Oil-Adjuvant Type

THE use of vaccines of the mineral-oil-adjuvant type in influenza-immunization procedures has the potential advantage of reducing the number of injections and amount of antigen required while producing antibodies in high titer for a prolonged period. Untoward reactions associated with these adjuvant preparations have been minor and relatively few, except when certain impure lots of the emulsifying agent, arlacel A, were employed. The impurities in certain lots of this agent have been implicated in the development of cysts and sterile abscesses after immunization.1 , 2 A potential hazard exists, however, as with aqueous preparations, that in addition to immunity to the desired . . .