Why the study?
Does the addition of purified antithrombin III with or without gabexate mesilate improve preservation of circulating AT-III during cardiopulmonary bypass in patients undergoing elective myocardial revascularization with preoperative heparin treatment?
Population
30 patients scheduled for elective myocardial revascularization and having undergone preoperative heparin…
Comparison
Group A: standard heparinization plus two doses… vs Standard heparinization
Design
RCT, randomized
Follow-up
intraoperative
Authors
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Supports adjunctive gabexate mesilate with AT-III in heparin-pretreated CPB patients; extends RCT evidence for heparin sparing and AT-III preservation.
Does the addition of purified antithrombin III with or without gabexate mesilate improve preservation of circulating AT-III during cardiopulmonary bypass in patients undergoing elective myocardial revascularization with preoperative heparin treatment?
The addition of gabexate mesilate and purified antithrombin III to heparin during cardiopulmonary bypass decreases heparin requirements and increases AT-III preservation in heparin-pretreated patients.
Ranucci et al. (1999) studied this question.
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