Key result
Plasmapheresis to reduce anti-P titer in a P1k woman with 13 prior early abortions suggests that anti-P can induce immunologically mediated early abortion.
Why the study?
Does plasmapheresis prevent early abortion in P1k women with anti-P antibodies?
Case Report (n=1)
Does plasmapheresis prevent early abortion in P1k women with anti-P antibodies?
This case report provides serologic evidence supporting the role of anti-P antibodies in immunologically mediated early abortion in Pk and p women.
May implicate anti-P in recurrent abortion; leaves open whether plasmapheresis prevents early loss in P1k women.
The current report details the serologic findings in a case reported previously of a P1k woman, para 0 gravida 13, who was treated during her fourteenth pregnancy with plasmapheresis to reduce the anti-P titer. These studies suggest that anti-P can induce early abortion in Pk women and that the abortions are immunologically mediated. Further, this case supports the disputed proposal that the anti-P component of anti-PP1Pk is responsible for pregnancy loss in p women.
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Shirey et al. (1987) conducted a case report in Recurrent early abortion associated with anti-P antibodies (n=1). Plasmapheresis was evaluated on Early abortion. Plasmapheresis to reduce anti-P titer in a P1k woman with 13 prior early abortions suggests that anti-P can induce immunologically mediated early abortion.
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