Key result
Long non-coding RNAs play a pivotal role in regulating cholesterol homeostasis and offer potential therapeutic targets for treating lipid-related diseases such as cardiovascular and liver diseases.
Why the study?
Given the high abundance of lncRNAs and poor genetic conservation between species, the specific role and mechanisms of lncRNAs in regulating cholesterol homeostasis require elucidation.
LncRNAs are emerging as crucial regulators of cholesterol homeostasis and represent potential therapeutic targets and biomarkers for lipid-related diseases such as atherosclerosis.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for lncRNA biomarkers in atherosclerosis; prospective validation required before clinical use.
Maintaining cholesterol homeostasis is essential for normal cellular and systemic functions. Long non-coding RNAs (lncRNAs) represent a mechanism to fine-tune numerous biological processes by controlling gene expression. LncRNAs have emerged as important regulators in cholesterol homeostasis. Dysregulation of lncRNAs expression is associated with lipid-related diseases, suggesting that manipulating the lncRNAs expression could be a promising therapeutic approach to ameliorate liver disease progression and cardiovascular disease (CVD). However, given the high-abundant lncRNAs and the poor genetic conservation between species, much work is required to elucidate the specific role of lncRNAs in regulating cholesterol homeostasis. In this review, we highlighted the latest advances in the pivotal role and mechanism of lncRNAs in regulating cholesterol homeostasis. These findings provide novel insights into the underlying mechanisms of lncRNAs in lipid-related diseases and may offer potential therapeutic targets for treating lipid-related diseases.
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Ye et al. (2021) conducted a review in Lipid-related diseases. lncRNA-targeted therapies was evaluated. Long non-coding RNAs play a pivotal role in regulating cholesterol homeostasis and offer potential therapeutic targets for treating lipid-related diseases such as cardiovascular and liver diseases.
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