Key result
Long non-coding RNAs play a critical regulatory role in glucose and lipid metabolism under both physiological and pathological conditions, offering potential as diagnostic biomarkers and therapeutic targets.
Why the study?
Long noncoding RNAs regulate glucose and lipid metabolism under physiological and pathological conditions, but an updated synthesis of their regulatory roles across various diseases was needed.
This review highlights the emerging role of long non-coding RNAs as key regulators of glucose and lipid metabolism, suggesting their potential as future diagnostic biomarkers and therapeutic targets for metabolic disorders.
Long noncoding RNAs (lncRNAs) are a type of noncoding RNA with a length that exceeds 200 nucleotides. Previous studies have shown that lncRNAs play an important role in the pathogenesis of various diseases. Research in both animal models and humans has begun to unravel the profound complexity of lncRNAs and demonstrated that lncRNAs exert direct effects on glucose and lipid metabolism both in vivo and in vitro. Such research has elucidated the regulatory role of lncRNAs in glucose and lipid metabolism in human disease. lncRNAs mediate glucose and lipid metabolism under physiological and pathological conditions and contribute to various metabolism disorders. This review provides an update on our understanding of the regulatory role of lncRNAs in glucose and lipid metabolism in various diseases. As our understanding of the function of lncRNAs improves, the future is promising for the development of new diagnostic biomarkers that utilize lncRNAs and treatments that target lncRNAs to improve clinical outcomes.
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Zhang et al. (2020) conducted a review in Glucose and lipid metabolism disorders. Long non-coding RNAs (lncRNAs) was evaluated. Long non-coding RNAs play a critical regulatory role in glucose and lipid metabolism under both physiological and pathological conditions, offering potential as diagnostic biomarkers and therapeutic targets.
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