Key result
Ankle-brachial index < 0.9 demonstrated higher sensitivity (91.53% vs 61.02%) and specificity (100% vs 98.18%) than carotid intima-media thickness > 0.63 mm for detecting significant CAD.
Why the study?
Does Ankle-brachial index (ABI) or Carotid intima-media thickness (CIMT) provide better diagnostic utility as a surrogate marker for significant coronary atherosclerosis in South Indians?
Case-Control (n=114)
Does Ankle-brachial index (ABI) or Carotid intima-media thickness (CIMT) provide better diagnostic utility as a surrogate marker for significant coronary atherosclerosis in South Indians?
p-value: p=<0.0001
ABI < 0.9 is a better surrogate marker of significant coronary atherosclerosis than CIMT > 0.63 mm in South Indians with CAD.
ABI may outperform CIMT as a CAD surrogate in South Indians; hypothesis-generating and requires prospective validation before clinical adoption.
AIM: We aimed to compare Ankle-brachial index (ABI) and Carotid intima-media thickness (CIMT) as surrogate markers of significant coronary atherosclerosis in South Indians with coronary artery disease (CAD). METHODS AND RESULTS: There were two groups: CAD group (n = 59) and Control group (n = 55). Mean ABI (0.82 ± 0.06 vs. 1.16 ± 0.11, p < 0.0001) and mean CIMT (0.74 ± 0.22 mm vs. 0.45 ± 0.09 mm, p < 0.0001) were statistically different between two groups. ABI < 0.9 (sensitivity: 91.53%, specificity: 100%) and CIMT > 0.63 mm (sensitivity: 61.02%, specificity: 98.18%) implied significant CAD. ABI and CIMT were negatively correlated to one another. With increasing severity of CAD, ABI decreased but CIMT increased. CONCLUSION: ABI and CIMT are simple noninvasive tools providing insight into coronary atherosclerosis. They can be done at bedside and easily repeated than coronary angiography. ABI < 0.9 is a better surrogate marker of significant coronary atherosclerosis than CIMT > 0.63 mm in South Indians with CAD.
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Babu et al. (2013) conducted a case-control in Coronary artery disease (n=114). Ankle-brachial index (ABI) and Carotid intima-media thickness (CIMT) vs. Control group was evaluated on Significant coronary atherosclerosis (p=<0.0001). Ankle-brachial index < 0.9 demonstrated higher sensitivity (91.53% vs 61.02%) and specificity (100% vs 98.18%) than carotid intima-media thickness > 0.63 mm for detecting significant CAD.
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