Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw

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Population

Rats (instep of the hind paw model)

Design

Preclinical

Authors

Discussion

Substance P may regulate cutaneous microvessel tone; leaves open translation to human microvascular disease.

Population

Rats (instep of the hind paw model)

Intervention

Antidromic stimulation of the sectioned sciatic nerve and pharmacological interventions (capsaicin, spantide, substance P infusion)

Outcome

Cutaneous blood flow (CBF) and tachykinin release into the subcutaneous spacesurrogate

Substance P released from small-diameter afferent fibers plays a key role in regulating vascular tone in cutaneous microvessels.

Yonehara et al. (1992) studied this question.

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