Key result
1,2-dioctanoylglycerol and PMA significantly reduced thrombin-induced intracellular Ca2+ mobilisation and arachidonate release by 20-80%, whereas 1-oleoyl-2-acetylglycerol had no such effect.
Population
Washed human platelets
Design
Preclinical
Authors
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Animal platelet data on DAG analogue effects are hypothesis-generating; leaves open translation to human platelet inhibition.
Oco2Gro is a more effective diacylglycerol analogue than OleAcGro for inhibiting agonist-induced platelet responses, likely due to more sustained protein kinase C activation.
Krishnamurthi et al. (1987) studied this question. 1,2-dioctanoylglycerol (Oco2Gro) and 1-oleoyl-2-acetyl-glycerol (OleAcGro) vs. Control / PMA was evaluated on Agonist-induced platelet activation processes (intracellular Ca2+ mobilisation, arachidonate/thromboxane B2 release, 5-hydroxytryptamine secretion). 1,2-dioctanoylglycerol and PMA significantly reduced thrombin-induced intracellular Ca2+ mobilisation and arachidonate release by 20-80%, whereas 1-oleoyl-2-acetylglycerol had no such effect.
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