Off the rac. Directed evolution of the amine oxidase from Aspergillus niger (MAO-N), by using 1-methyltetrahydroisoquinoline as the target substrate, led to the identification of a variant enzyme (Asn336Ser/Ile246Met) that possessed a greater kcat value (5.5-fold) than the parent as well as high enantioselectivity (see scheme). This new variant was used for the deracemisation of cyclic secondary amines on a preparative scale.
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Carr et al. (2005) studied this question.
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