Rational Design of Bioorganometallic Foldamers: A Potential Model for Parallel β‐Helical Peptides

Twists and turns: A series of alanine conjugates of ferrocene amino acid (Fca) were prepared based on the idea that an alternating sequence of a natural α-amino acid and a turn-inducing molecule may result in the formation of a robust model foldamer for β-helical peptides. Right- and left-handed pseudo-β-helical Fca–alanine foldamers were obtained, and their structures were studied in solution and the solid state.