Modified, pulse field gradient‐enhanced inverse‐detected HOESY pulse sequence for reduction of t1 spectral artifacts

A modified pulse field gradient (PFG)‐enhanced inverse (1H)‐detected 2D heteronuclear Overhauser effect spectroscopy (HOESY) pulse sequence is demonstrated for the acquisition of 1H–7Li heteronuclear correlations. In practice, t1 noise artifacts were observed using the original PFG‐enhanced inverse‐detected HOESY pulse sequence, which degraded the ability to detect accurately weak heteronuclear Overhauser signals. Experimentally it is shown that a simple modification of the PFG‐enhanced inverse‐detected HOESY pulse sequence greatly reduces the t1 noise that may result from variations in magnetic susceptibility, and allows improved detection of weak 1H–7Li correlations.