Key result
Higher brachial ankle pulse wave velocity (baPWV) and carotid-femoral PWV (cfPWV) were independently associated with an increased risk of coronary artery disease.
Why the study?
Are arterial stiffness markers (baPWV and cfPWV) associated with an increased risk of coronary artery disease?
Case-Control (n=660)
No
Are arterial stiffness markers (baPWV and cfPWV) associated with an increased risk of coronary artery disease?
Arterial stiffness, measured by baPWV and cfPWV, is independently associated with the risk of coronary artery disease and interacts with traditional risk factors like age and lipid levels.
Arterial stiffness markers may refine CAD risk assessment; hypothesis-generating in case-control data and requires prospective validation before practice change.
OBJECTIVE: To investigate the role of Brachial ankle Pulse Wave Relocity (baPWV) and cfPWV on the risk of Coronary artery disease and the interaction between baPWV and risk factors of Coronary artery disease (CAD). METHODS: A case-control study was conducted at Department of Emergency, SunYat-Sen memorial Hospital, China. We collected 332 cases with coronary artery disease and 328 subjects without CAD between February 2012 and October 2013. A multivariate logistic regression analysis was performed to analyze the risk factors of CAD. RESULTS: CAD subjects were more likely to be old age, and have higher BMI, waist-hip ratio, hypertension, fasting glucose, TG, carotid-femoral PWV (cfPWV) and baPWV, and CAD subjects had a lower TC, HDL-C and LDL-C. We found that older age, smoking, higher hypertension, TC, TG, HDL-C, LDL-C, carotid-femoral PWV (CfPWV) and baPWV were associated with risk of CAD. baPWV had significant interaction with age, TC, TG, HDL-C and LDL-C, carotid-femoral PWV (cfWV) was correlated with age, HDL-C and LDL-C. CONCLUSION: This study showed that baPWV and cfPWV are two independent factors for the risk of Coronary artery disease, and baPWV and cfPWV have interaction with age, TC, TG, HDL-C and LDL-C.
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Feng et al. (2014) conducted a case-control in Coronary artery disease (n=660). Brachial ankle Pulse Wave Velocity (baPWV) and carotid-femoral PWV (cfPWV) vs. Lower PWV / Subjects without CAD was evaluated on Risk of coronary artery disease. Higher brachial ankle pulse wave velocity (baPWV) and carotid-femoral PWV (cfPWV) were independently associated with an increased risk of coronary artery disease.
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