The cyclophane 1 is the first functional model for the enzyme pyruvate oxidase in which flavin and thiazolium prosthetic groups are arranged close to a well-defined binding site. It catalyzes the oxidation of 2-naphthaldehyde to methyl 2-naphthoate in MeOH/Et3N with high efficiency and complete reaction selectivity.
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Mattei et al. (1996) studied this question.
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