New Scalable Asymmetric Aminomethylation Reaction for the Synthesis of β2‐Amino Acids

Abstract β‐Amino acids are useful tools in the design of peptidomimetics, and the development of new methods for their syntheses, particularly the synthesis of β2‐amino acids, remains an important challenge. Here we report a new scalable route based on the aminomethylation of silyl ketene N,O‐acetals by Mannich‐type iminium electrophiles. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)