The Design and Synthesis of a Scaffold for Combinatorial Chemistry Based on Bile Acid

A complete β-turn can be mimicked by the tetrapeptide mimetic 1, which can thus be built into peptides with unambiguous directionality. Mimetic 1 was prepared from chenodeoxycholic acid, and is very interesting as a building block for compound libraries of β-turn mimics. ℗ = polymer support.