Key result
A prosthetic left ventricle was presented as a novel approach to reduce the pressure against which a diseased ventricle must eject its stroke volume.
The study introduces a novel conceptual approach for a prosthetic left ventricle that provides continuous pressure assistance to reduce the pressure work of a diseased ventricle.
Requires preclinical validation before any clinical testing; leaves open feasibility of prosthetic pressure assistance in advanced HF.
Two BASIC approaches to the development of an "artificial heart" have been introduced by several groups of investigators: total replacement of the diseased heart by pumps contained within the vacated pericardial space1-8and intrathoracic bypass pumps which divert the flow of blood past the diseased ventricle or ventricles, thus reducing the flow work9,10(Fig 1). The inlet of such a pump is anastomosed to the left atrium and the outlet is anastomosed to the aorta. Inlet (mitral) and outlet (aortic) prosthetic valves must be provided to assume the function of mitral and aortic valves respectively. A third basic approach is presented in this study (Fig 2). The prosthetic ventricle serves to reduce the pressure against which the disease ventricle must eject its stroke volume to the extent that the diseased ventricle is performing the function of an auxiliary left atrium. The pressure work of the physiologic ventricle is
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William C. Birtwell (1965) studied Diseased heart. Prosthetic left ventricle was evaluated. A prosthetic left ventricle was presented as a novel approach to reduce the pressure against which a diseased ventricle must eject its stroke volume.
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