Time trends of intestinal and diffuse types of gastric cancer in the United States

This is the authors' abstract. We don't add key points for this paper.

All histologically confirmed gastric cancer cases diagnosed during the periods 1940–1944 and 1960–1964 at the Hartford Hospital were classified into three groups: intestinal, difuse and others, according to a modified Laurén's classification. A reduction in the frequency of intestinal type carcinoma was observed between the earlier and the later time periods. Although this decrease was not statistically significant, it persisted within each sex. The cases were also subdivided into high‐ and low‐risk groups according to the risk for gastric cancer prevailing at their place of birth. As expected, the intestinal type carcinoma was the most predominant in the high‐risk group. This predominance persisted within each sex and time period category and it was more noticeable among female than among male cases. These findings support the hypothesis that these two types of gastric cancer, intestinal and difluse, differ not only structuraily and epidemiologically, but also etiologically.