Chiral copper-salen complex grafted over functionalized mesoporous silica as an efficient catalyst for asymmetric Henry reactions and synthesis of the potent drug ( R )-isoproterenol

A new chiral Cu( ii )@AFS-1 catalyzed asymmetric Henry reaction (ee = 94%, yield 96%) and diastereoselective Henry reaction have been reported. Additionally, drug ( R )-(−)-isoproterenol was synthesized using this protocol.