Enantioselective Total Synthesis of Dysidavarone A, a Novel Sesquiterpenoid Quinone from the Marine Sponge Dysidea avara

This is the authors' abstract. We don't add key points for this paper.

Dysidavarone A, a structurally unprecedented sesquiterpenoid quinone, was synthesized in 30 % overall yield in a longest liner sequence of 13 steps from commercially available o-vanillin. A highly strained and bridged eight-membered carbocyclic core was established by the C7-C21 carbon bond formation through a copper enolate mediated Michael addition to the internal quinone ring.