Facile Access to Fluorinated Aryl and Vinyl Ethers through Copper‐Catalysed Reaction of Fluoro Alcohols

Fluorinated alcohols react with aryl and vinyl halides by copper‐catalysed cross‐coupling reactions to afford the corresponding ethers. With trifluoroethanol (TFE) the reaction proceeds with both iodides and bromides and a wide range of aromatic substituents are tolerated. When higher fluorinated homologues such as C7F15CH2OH were used, the corresponding products were obtained in good yields, thus offering an interesting entry to fluorous tagging. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)