The Enantioselective Synthesis of Phomopsin B

Proven approach to a family of antimitotics: The total synthesis of phomopsin B, an antimitotic natural product, was achieved by assembling two fragments of equal complexity in a longest linear sequence of 26 steps. The approach features two catalytic transformations that set multiple stereocenters in single steps (red and blue boxes) and a general strategy for the preparation of dehydrated amino acids (green box).