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All articles of this category Mono-, di- and trisubstituted tert -butyl 5-amino-4-alkenoates 3 and mono- or disubstituted tert -butyl 5-oxoalkanoates 4 are prepared in good overall yield by conjugate addition of ß-lithiated enamines to enoates, followed by quenching with water or iodo-methane. In all cases, only one stereoisomer of the polysubstituted enamino esters 3 is produced (de > 98%).
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Duhamel et al. (1991) studied this question.
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