Carbenicillin administration in patients with severe renal failure.

, Jones and Lowbury (1967), and Brumfitt, Percival, and Leigh (1967) have demon- strated that the majority of Pseudomonas aeruginosa strains are inhibited by a carbenicillin concentration of 100 /Lg./ml. Carbenicillin is very rapidly excreted in the urine under normal circumstances, however, and Knudsen et al. (1967) have shown that in patients with normal renal function it would be necessary to administer 1 g. of carbenicillin intravenously every hour together with probenecid in order to maintain serum levels of 100 .tg./ml.