Ugi-Smiles Access to Quinoxaline Derivatives

This is the authors' abstract. We don't add key points for this paper.

Two different Ugi-Smiles post-condensations strategies have been used for new three and four-component formation of quinoxaline scaffolds.In the first approach, a one-pot hydrogenation-cyclization affords the heterocycle with loss of the initial isocyanide moiety.In the second one, the use of o-iodonitrophenol as starting phenol, coupled with copper catalyzed cyclization gave us similar quinoxaline derivatives resulting from a four coupling.