The kinetically controlled diastereoselectivity in the bromine/lithium exchange reaction of the dibromoalkanes 6 and 7 has been found to be moderate (75:25) and (67:33). The thermodynamic ratio of the epimeric organolithium compounds 12a/b and 17a/b, respectively, has been determined to coincide with the kinetic ratios given above.
No takes yet. Share an insight, caveat, or question.
Hoffmann et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: