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High affinity for the four-center binding site of a monoclonal antibody is a feature of the spacer-modified trisaccharide 1, in which one monosaccharide residue has been replaced by an appropriately long open-chain link. The connecting link is in turn provided with a reactive functional group. Thanks to its affinitylabeling characteristics, compound 1 is capable of “sounding out” the binding site of the title antibody.
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Glaudemans et al. (1989) studied this question.
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