Key result
Pulmonary vein banding in a swine model induced metabolic changes in the upper lobes pertaining to fatty acid metabolism, ROS signaling, and extracellular matrix remodeling.
Why the study?
Pulmonary vein stenosis causes a rare type of pulmonary hypertension through hemodynamic changes and metabolic alterations, prompting investigation into the molecular alterations that drive PH development.
Pulmonary vein banding in a swine model induces distinct regional metabolic alterations, highlighting potential molecular targets for pulmonary vein stenosis-induced pulmonary hypertension.
Pulmonary vein stenosis (PVS) causes a rare type of Pulmonary Hypertension (PH), by impacting the flow and pressure within the pulmonary vasculature resulting in endothelial dysfunction and metabolic changes. A prudent line of treatment in this type of PH would be targeted therapy in order to relieve the pressure and reverse the flow related changes. We used a swine model in order to mimic PH post PVS using pulmonary vein banding (PVB) of the lower lobes for 12 weeks to mimic the hemodynamic profile associated with PH and investigate the molecular alterations that provide an impetus for development of PH. Our current study aimed to employ unbiased proteomic and metabolomic analyses on both the upper and lower lobes of the swine lung to identify the regions with metabolic alterations. We detected changes in the upper lobes for the PVB animals mainly pertaining to fatty acid metabolism, ROS signaling and extracellular matrix remodeling, and small albeit significant changes in the lower lobes for purine metabolism.
No takes yet. Share an insight, caveat, or question.
Sen et al. (2023) studied Pulmonary Hypertension. Pulmonary vein banding (PVB) of the lower lobes was evaluated on Proteomic and metabolomic alterations in the upper and lower lobes of the lung. Pulmonary vein banding in a swine model induced metabolic changes in the upper lobes pertaining to fatty acid metabolism, ROS signaling, and extracellular matrix remodeling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: