Why the study?
What factors contribute to postprandial glucose excursions and how can they be managed to potentially reduce cardiovascular disease risk?
What factors contribute to postprandial glucose excursions and how can they be managed to potentially reduce cardiovascular disease risk?
This review highlights the importance of managing postprandial glucose excursions through diet and medication to potentially mitigate cardiovascular disease risk in Type 2 diabetes.
May support low-GI diets and pharmacotherapy for postprandial glucose in T2D; hypothesis-generating for CVD benefit pending prospective trials.
Disturbances of postprandial glucose metabolism are now thought to contribute to cardiovascular disease. Postprandial glucose excursions can be affected by a number of factors, such as the types of carbohydrates ingested and the way they are metabolized. In Type 2 diabetes, factors that contribute to excessive postprandial glucose excursions include disruption of insulin secretion, insufficient inhibition of hepatic glucose production and defective glucose storage in muscle. A number of measures may attenuate excessive postprandial blood glucose excursions. These include a diet high in 'low glycaemic index' foods and treatment with drugs that improve or restore the hormonal response (e.g. the sulphonylureas and the newer beta-cell mediated insulinotropic drugs such as repaglinide), that improve insulin sensitivity or that delay gastric emptying.
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Lefèbvre et al. (1999) studied this question.
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