Key result
Acute gamma irradiation of the precordium reduced left ventricular ejection fraction by day 58 in all irradiated dogs, paralleling the onset of cardiac fibrosis.
Why the study?
Does acute gamma irradiation of the precordium induce cardiac dysfunction in adult beagle dogs?
Does acute gamma irradiation of the precordium induce cardiac dysfunction in adult beagle dogs?
Answers are grounded in this paper and cite their sources.
Acute gamma irradiation of the precordium in dogs leads to a delayed reduction in LVEF that parallels the onset of cardiac fibrosis.
In order to study the development of post-irradiation cardiac dysfunction, we irradiated the precordia of 18 adult beagle dogs with 30, 60, or 100 Gy of Co-60 photons, and measured cardiac histology, electrocardiograms, Tc-99, pyrophosphate cardiac tissue distribution, and serial left ventricular ejection fraction (LVEF). Although the electrocardiograms and tissue distribution of Tc-99m were unaffected by these dose levels, the LVEF was reduced by day 58 for all the irradiated dogs. The delay in the onset of cardiac function impairment parallels the delay in the onset of fibrosis in irradiated hearts.
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Asaf Duraković (1986) studied post-irradiation cardiac dysfunction (n=18). Acute Gamma Irradiation of the Precordium was evaluated on left ventricular ejection fraction (LVEF). Acute gamma irradiation of the precordium reduced left ventricular ejection fraction by day 58 in all irradiated dogs, paralleling the onset of cardiac fibrosis.
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