Key result
Piglets born to sows vaccinated with the China strain of classical swine fever virus did not all have detectable maternal antibodies, indicating variable passive immunity.
Why the study?
Does maternal vaccination with China strain vaccine provide passive immunity against classical swine fever virus in piglets?
Population
35 piglets at ages 28, 35, 44, and 54 days
Comparison
Challenge with classical swine fever virus via… vs Piglets originating from non CSF vaccinated sows
Design
Preclinical
Follow-up
up to 29 days post-challenge
Authors
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Variable passive immunity after China strain sow vaccination warrants caution in assuming uniform piglet protection; leaves open optimized protocols.
Does maternal vaccination with China strain vaccine provide passive immunity against classical swine fever virus in piglets?
Maternal vaccination with the China strain of classical swine fever virus does not guarantee detectable passive immunity in all offspring.
Došen et al. (2007) studied Classical swine fever (CSF) infection (n=35). Maternal vaccination with China strain of classical swine fever virus vs. Piglets derived from unvaccinated sows was evaluated on Presence of CSF virus specific antibodies and viral antigen/RNA. Piglets born to sows vaccinated with the China strain of classical swine fever virus did not all have detectable maternal antibodies, indicating variable passive immunity.