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DNA fibre autoradiography has been used to study the replication of chromosomal DNA from chicken cells in tissue culture at 37 °C. The S-phase is estimated to be about 7·5 h. Replication proceeds in the manner first described by Huberman & Riggs. Tandemly arranged units replicate bi-directionally from fork-like growing points, the times of initiation of individual repheating sections being staggered. Evidence against the existence of defined termini is presented. The rate of replication in these chicken cells is some 25–30 μm/h one-way. The mean interval between adjacent initiation points for replication is 63 μm, with a range of some 25–145 μm. Although initiation intervals vary in length, neighbouring intervals tend to be similar in length.
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Mcfarlane et al. (1973) studied this question.
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