Key result
Severe perioperative bleeding occurred in 3.4% to 5.9% of low-risk patients undergoing CABG and was associated with an increased risk of death, stroke, and acute kidney injury.
Why the study?
Does perioperative bleeding and transfusion increase the risk of adverse events in low-risk patients undergoing CABG?
Population
1,213 low-risk patients undergoing coronary artery bypass grafting across 16 European centers.
Comparison
Perioperative bleeding and blood transfusion vs No bleeding or lower grades of bleeding
Design
Cohort
Authors
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Bleeding signals excess risk even in low-risk CABG; hypothesis-generating for prevention trials, should not yet change practice.
Cohort (n=1,213)
Yes
Does perioperative bleeding and transfusion increase the risk of adverse events in low-risk patients undergoing CABG?
Even in low-risk patients undergoing CABG, severe perioperative bleeding is associated with a significantly increased risk of major adverse events like death, stroke, and AKI.
Kinnunen et al. (2016) conducted a cohort in Low-risk patients undergoing coronary artery bypass grafting (CABG) (n=1,213). Perioperative bleeding and blood transfusion vs. No or mild bleeding was evaluated on Adverse events including death, stroke, and acute kidney injury. Severe perioperative bleeding occurred in 3.4% to 5.9% of low-risk patients undergoing CABG and was associated with an increased risk of death, stroke, and acute kidney injury.
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