Key result
Chronic administration of isosorbide-5-mononitrate causes endothelial dysfunction and oxidative stress, mediated by endothelin-dependent activation of vascular and phagocytic NADPH oxidase.
Why the study?
Does chronic isosorbide-5-mononitrate administration cause endothelial dysfunction and oxidative stress in experimental models?
Does chronic isosorbide-5-mononitrate administration cause endothelial dysfunction and oxidative stress in experimental models?
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Chronic use of isosorbide-5-mononitrate causes endothelial dysfunction and oxidative stress in animal models, raising concerns about the long-term safety of organic nitrates and suggesting a need to re-evaluate current therapeutic strategies.
Rassaf et al. (2012) conducted an editorial in Endothelial dysfunction. Isosorbide-5-mononitrate was evaluated. Chronic administration of isosorbide-5-mononitrate causes endothelial dysfunction and oxidative stress, mediated by endothelin-dependent activation of vascular and phagocytic NADPH oxidase.
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